Role of Quercetin in DNA Repair and Dysregulated Metabolism. Possible Target to Combat Drug Resistance in Cancer

Authors

  • Waqas Alam Abdul Wali Khan University Mardan
  • Arif Ali Federal University of Ceará, Fortaleza, CE, Brazil
  • Faizullah khan University of Nizwa
  • Alice Maria Costa Martins Federal University of Ceará, Fortaleza, CE, Brazil
  • Yaseen Hussain College of Pharmaceutical Sciences
  • Haroon Khan Abdul Wali Khan University Mardan

Keywords:

Lumpy skin disease, phytochemicals, Endemic, Asia, antibiotics alternatives

Abstract

ONE of the biggest challenges in medicine is finding a remedy for cancer. Earlier to 1950, surgery was thought to be the main form of treatment for cancer. Later, radiation therapy was added as a second method to treat localized tumours. Cancer drug development have modified into billion-dollar industry supported by the advent of novel targeted therapies; however, the basic principles and limitation of chemotherapy are still the same. For instance, chemotherapy is associated with increase psychological distress, fatigue, anxiety accompanied by intense financial distress ultimately causing decrease quality of life. Dietary nutrients, calories limitation and fasting are known to have a large impact in modifying many types of diseases including cancer, and obesity. Quercetin a plant derived flavonoid found abundantly in fruits, vegetables and many beverages possess multiple pharmacological activities shows encouraging potential in treatment and prevention of various types of cancers. Quercetin aglycone has also been shown to modulate several signal transduction pathways involving MEK/ERK and Nrf2/keap1, which are associated with the processes of inflammation and carcinogenesis. Quercetin is an attractive natural compound for cancer prevention due to its beneficial anti-mutagenic and anti-proliferative effects, its strong antioxidative capacity, and its role in the regulation of cell signaling, cell cycle and apoptosis, all demonstrated in animal and in vitro studies. The aim of the present review is to summarize the key aspects of quercetin role, mechanisms, and future prospects in treating and prevention of cancer by modulating DNA repair, metabolism and drug resistance.

Downloads

Download data is not yet available.

Author Biographies

Waqas Alam, Abdul Wali Khan University Mardan

1Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Pakistan

Arif Ali, Federal University of Ceará, Fortaleza, CE, Brazil

Postgraduate Program in Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil;

Faizullah khan, University of Nizwa

Natural and Medical Sciences Research Center NMSRC, University of Nizwa, Nizwa 616, Sultanate of Oman

Alice Maria Costa Martins, Federal University of Ceará, Fortaleza, CE, Brazil

Department of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza, CE, Brazil;

Yaseen Hussain, College of Pharmaceutical Sciences

Lab of Controlled Release and Drug Delivery System, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China

Haroon Khan, Abdul Wali Khan University Mardan

Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Pakistan

Downloads

Published

2022-11-27

Issue

Section

Articles