PHYTONutrients <p><strong>PHYTONutrients</strong></p> <p>The Journal of PHYTONutrients is primarily a therapeutic journal, that aims to bring together major scientific disciplines in this vast field in order to address the most pressing questions and developments. Our goal is to build a reputable knowledge forum in the domains of human health by creating an integrated podium based on efficacy, safety, quality, and mechanisms of action of specified plant-derived nutrients in the form of original research, clinical trials, and contemporary reviews/meta-analysis. We welcome manuscripts for our dedicated sections relating to various areas of plant-nutrition with a focus on human health through an open-access platform.</p> <p><strong>Striking Reasons — why publish in PHYTONutrients </strong></p> <ul> <li>Open Access will result in more downloads and citations of your article.</li> <li>Article publication charges are waived until January 2024.</li> <li>Quality is assured with a robust peer-review process.</li> <li>Rapid publication as a first decision is provided to authors approximately 20 days after submission; acceptance to publication is undertaken in 5 days.</li> <li>There is no space constraint.</li> <li>No charges for the use of color figures. </li> <li>There are no copyright restrictions. </li> <li>Reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in the journal. </li> </ul> <p> </p> <p><a href=""><strong>Read the author's guidelines</strong></a></p> <p> </p> <p><strong>Meet the Editors</strong></p> <div class="editor-div__content img-exists"> <p><img src="" alt="" width="120" height="154" /><br /><strong>Editor-in-Chief<br />Prof. Dr. Maria Daglia</strong> <br /><em>University of Naples, Naples, Italy<br />E.mail: <a href=""></a><br /></em><a href=";amp;eid=2-s2.0-84890468694" target="_blank" rel="noopener">Learn more about Prof. Daglia</a><br /><br /><br /></p> </div> <div style="clear: both;"><img src="" alt="" /></div> <div style="clear: both;"> <p><strong>Editor-in-Chief<br />Prof. Dr. Jianbo Xiao</strong> <br /><em>University of Vigo, Vigo, Spain<br />E.mail:<br /></em><a href="" target="_blank" rel="noopener">Learn more about Prof. Xiao</a></p> </div> LYCEUM PUBLISHER (PRIVATE) LIMITED en-US PHYTONutrients Introduction to Editor in Chief <p>Dr. Jianbo Xiao is current a full professor of University of Vigo (Spain). He received PhD degree in nutrition from Okayama Prefectural University (Japan) in 2009. He worked as a Postdoc supported by AvH foundation at University of Würzbug, Germany (April 2013-May 2015) and then worked as an assistant professor in University of Macau (October 2015-December 2020). Dr. Xiao has been selected as Clarivate Analytics Highly Cited Researchers (2016, 2017, 2019, 2020 and 2021). His research is focusing on natural polyphenols. He has accepted and published more than 300 peer reviewed papers including Nature Reviews Drug Discovery, Seminars in Cancer Biology, Biotechnology Advances, Trends in Food Science &amp; Technology, Critical Reviews in Food Science and Nutrition, Acta Pharmaceutica Sinica B, Pharmacological Research, Journal of Advanced Research, Food Chemistry, and so on (Citation: 17100, H-index 67).</p> <p>He also works as the chairman to organize ISPMF2015, 2-ISPMF (2017), 3-ISPMF (2018), 4-ISPMF (2020) and 4-ISPMF (2021). Dr. Xiao is the editor-in-chief of Food Frontiers (Wiley) and World Journal of Diabetes (IF 4.56), the Associate Editor of Journal of Advanced Research (IF 12.822), Frontiers in Pharmacology (IF 5.988), Journal of Berry Research (IF 2.156), and Phytomedicine Plus (Elsevier), the academic editor of Oxidative Medicine and Cellular Longevity (IF 7.31), the section editor of Current Neuropharmacology (IF 7.708), and the editorial board member of Trends in Food Science &amp; Technology (IF 16.002), Critical Reviews in Food Science and Nutrition (IF 11.208), Food Science and Human Wellness (IF 8.022), Phytomedicine (IF 6.656), Industrial Crops and Products (IF 6.449), Current Research in Food Science (IF 6.269), International Journal of Molecular Sciences (IF 6.208), Journal of Nutritional Biochemistry (IF 6.117), Molecules (IF 12.882), Foods (IF 5.561), Current Drug Metabolism (IF 3.408), Anti-Cancer Agents in Medicinal Chemistry (IF 2.505), Food Chemistry: Molecular Sciences, and so on.</p> Prof. Jianbo Xiao Copyright (c) 2022 PHYTONutrients 2022-11-27 2022-11-27 01 01 Oxyria digyna: A review on the nutritional value, phytochemistry and ethnopharmacology <p><em>Oxyria digyna</em> is an important herb, having a wide geographical distribution. Nutritionally, it has found its place in the meals of various populations living in different parts of the world, both in raw and cooked forms. Traditional uses identified its indications in cancer, depression, hepatitis, jaundice, colic, gastritis, appetite, diuretic, constipation, cough, chest congestion, boils, scurvy. Several pharmacological activities have hastened further experimental exploration of this plant, establishing its efficacy for diabetes, free radical scavenging, gout, and cancer. The important bioactive compounds isolated from this plant are vitexin, orientin, hesperidin, quercetin and stigmasterol. These compounds have extensive effects on human physiology and provide proof that <em>O. digyna</em> is potentially unexplored for its pharmacological efficacy. A detailed metabolomic approach is required to fully characterize the plant as a potential nutraceutical candidate with multiple therapeutic potentials.</p> Imad Ahmad Luigi Milella Ghallab Alotaibi Copyright (c) 2022 PHYTONutrients 2022-11-27 2022-11-27 02 16 Curcumin targeting oxidative mediators for therapeutic effects in diabetes and its related complications <p><strong>DIABETES</strong> mellitus is a multifactorial chronic metabolic disorder characterized by altered metabolism of macro – nutrients such fats, proteins and carbohydrates associated with disturbances in insulin activity. Diabetes mellitus complications include, diabetic retinopathy, diabetic cardiomyopathy, diabetic encephalopathy, diabetic periodontitis and diabetic nephropathy. These complications are mostly induced by inflammatory and oxidative mediators. Curcumin is a polyphenol extracted from turmeric and it is well known for its antioxidant, anti-inflammatory and antiapoptotic activities. It effectively targets oxidative mediators in diabetes mellitus through regulation of several signaling pathways. Insulin resistance is commonly caused due to impairment in the signaling pathways related to insulin and the target tissues pose lesser or no response to circulating insulin. Curcumin is a potent therapeutic agent that targets oxidative stress mediators in diabetes mellitus and its resistant version leading to favorable therapeutic outcomes in diabetes complications. This review has thrown sufficient light on the therapeutic potential of curcumin targeting oxidative mediators in diabetes and its related complications. <strong>&nbsp;&nbsp;</strong></p> Yaseen Hussain Haroon Khan Waqas Alam Zakir Ali Muhammad Ibrar Copyright (c) 2022 PHYTONutrients 2022-11-27 2022-11-27 17 35 Role of Quercetin in DNA Repair and Dysregulated Metabolism. Possible Target to Combat Drug Resistance in Cancer <p><strong>ONE</strong> of the biggest challenges in medicine is finding a remedy for cancer. Earlier to 1950, surgery was thought to be the main form of treatment for cancer. Later, radiation therapy was added as a second method to treat localized tumours. Cancer drug development have modified into billion-dollar industry supported by the advent of novel targeted therapies; however, the basic principles and limitation of chemotherapy are still the same. For instance, chemotherapy is associated with increase psychological distress, fatigue, anxiety accompanied by intense financial distress ultimately causing decrease quality of life. Dietary nutrients, calories limitation and fasting are known to have a large impact in modifying many types of diseases including cancer, and obesity. Quercetin a plant derived flavonoid found abundantly in fruits, vegetables and many beverages possess multiple pharmacological activities shows encouraging potential in treatment and prevention of various types of cancers. Quercetin aglycone has also been shown to modulate several signal transduction pathways involving MEK/ERK and Nrf2/keap1, which are associated with the processes of inflammation and carcinogenesis. Quercetin is an attractive natural compound for cancer prevention due to its beneficial anti-mutagenic and anti-proliferative effects, its strong antioxidative capacity, and its role in the regulation of cell signaling, cell cycle and apoptosis, all demonstrated in animal and in vitro studies. The aim of the present review is to summarize the key aspects of quercetin role, mechanisms, and future prospects in treating and prevention of cancer by modulating DNA repair, metabolism and drug resistance.</p> Waqas Alam Arif Ali Faizullah khan Alice Maria Costa Martins Yaseen Hussain Haroon Khan Copyright (c) 2022 PHYTONutrients 2022-11-27 2022-11-27 36 47 Anxiolytic and antidepressant potential of extracts of Duchesnea Indica in animal models <p><strong>THIS</strong> study was designed to investigate the anxiolytic and antidepressant activity of <em>Duchesnea Indica</em>. The methanolic extract and <em>n-</em>hexane fraction of plant were tested in albino mice (20-30 g of 6-8 week). Safety profile of each extract was determined at different doses. Anxiolytic effect of plant was determined by Elevated Plus Maze and Light and Dark Model at different doses of methanolic and <em>n</em>-hexane extract. Antidepressant activities were assisted by Tail Suspension and Forced Swim Model at different doses. Result illustrated that <em>D. Indica</em> had a significant (<em>P</em> &lt; 0.05) potential of reducing anxiety and depression. The methanolic extract at 100 mg and 200 mg significantly increased the time spend in light region of light and dark model and more time spent in open arm of Elevated Plus Maze model. <em>n-</em>hexane extract at dose of 5 mg and 10 mg/kg significantly increases the time spend in light region of Light and dark model and more time spend in open arm of Elevated Plus Maze model as compare to Control group. <em>Methanolic</em> extract of <em>D. Indica</em> significantly reduced the time of immobility in Tail Suspension and Force Swim Model at Dose of 100 mg and 200mg/kg. n-hexane extract also exhibit anti-depressant effect by reducing the time of immobility in Force swim and tail suspension Model at 100 mg and 200mg/kg dose as compare to control group. From the above observations, it could be assumed that the plant has marked anxiolytic and antidepressant potential. However further additional studies will be necessary to determine the underlying exact mechanism and clinical uses.</p> Mohibullah Abdul Saboor Pirzada Michael Aschner Haroon Khan Copyright (c) 2022 PHYTONutrients 2022-11-27 2022-11-27 48 56 Anticancer Potential of Diospyros kaki (persimmon) polyphenols against AKT1 (6CCY): docking based in silico study <p>The elevation of AKT activity in many aggressive tumors, and AKT signaling is frequently compromised in various cancers. The range of AKT inhibitors' therapeutic effects extends beyond cancer management. AKT inhibitors may potentially be used to treat cancer. The study aims to find a potent drug compound from <em>D. kaki</em> polyphenols that could serve as an AKT1 inhibitor. <em>In silico</em> study using Molecular operating environment (MOE) software was employed to find the therapeutic potential of phytochemicals from <em>D. kaki</em> against AKT1 via molecular docking and drug-like properties. Results of the study revealed that acarbose (<strong>compound 1</strong>) has the highest docking score of -7.4615 with receptor protein 6CCY, followed by quercetin 3-O-glucoside (<strong>compound 2</strong>) with a docking score of -6.86404133 measured in terms of kcal/mol. Pocket residues involved in protein-ligand interaction was GLU234, GLU278, ASP292, ASN79, LYS276, LYS189, PHE161, HIS194, LYS179, ASP291, LYS158, GLU278. Thus, bioactive compounds from <em>D. kaki</em> may be a potentially novel anticancer agent by inhibiting AKT1.</p> Ijaz Muhammad Gul E Nayab Noor Rahman Sadaf Niaz Abid Ali Haroon Khan Copyright (c) 2022 PHYTONutrients 2022-11-27 2022-11-27 57 68