The effect of crocin on the proliferation, inflammation, drug synergism, and angiogenesis in breast cancer

2024-10-09T11:30:13+00:00

Radiation, chemotherapy, and surgery are common treatments for breast cancer. These approaches, however, could only improve the odds of surviving. Using herbal medicines like crocin is now necessary to improve cancer treatment, particularly for breast cancer. According to research, crocin inhibits the growth of cancerous cells while having no effect on the development of healthy cells. By eating this substance, the side effects of cancer chemotherapy are also reduced. Thus, this review delves into the effects of crocin on breast cancer, encompassing anti-angiogenesis, drug synergism, proliferation, and inflammation. Crocin decreases the expression of CD34 in tumor tissues, leading to anti-angiogenesis. Furthermore, the anti-angiogenic effect of crocin can hinder vascular endothelial cell proliferation, migration, and tubule formation in vitro, as well as tumor cell proliferation and reduction in microvascular density in vivo. Also, crocin increases the sensitivity of PTX in breast cancer cell lines.

Antioxidant Assays in Phytonutrient Research: Translating Laboratory Innovations into Practical Applications

2024-11-25T14:47:47+00:00

Background: There is great promise for improving nutrition and health thanks to phytonutrients' antioxidant qualities and health advantages. Their capacity to combat oxidative stress and associated illnesses emphasizes the importance of precisely evaluating their antioxidant characteristics. Objective: This study concludes by providing a comprehensive and critical critique of the current approaches to measure the antioxidant activity of phytonutrients. It dives into the fundamentals, benefits, drawbacks, and most recent developments of commonly used antioxidant assays, giving the reader a comprehensive grasp of the topic. This recapitulation of the review's goal in the end reinforces the reader's primary takeaway. Methods: Research on several antioxidant tests, such as FRAP, ORAC, DPPH, and ABTS, is consolidated in this review. It looks at each assay's performance traits, technological advances, and techniques. The review also assesses the incorporation of many assays to thoroughly examine phytonutrient potency and its uses in the food industry and nutritional science. Results: The review shows how antioxidant tests have advanced significantly, improving sensitivity, accuracy, and physiological relevance. It demonstrates how these tests can be used practically to guarantee food quality, create supplements, and offer nutritional advice. The paper also lists the difficulties today, including the intricacy of antioxidant mechanisms, test variability, and the requirement for assay standardization. The practical value of the research is emphasized by highlighting the significance of antioxidant tests for quality assurance, adulteration detection, and shelf life extension in the food business. Discussion: Scientists, doctors, and business experts interested in evaluating and applying phytonutrients will find this review helpful. It emphasizes how crucial it is to improve antioxidant testing to ascertain the possible health advantages and therapeutic uses of phytonutrients. The review highlights the need for increased test sensitivity, accuracy, and relevance while discussing the benefits and drawbacks of the available techniques. It draws attention to the importance of strong and trustworthy antioxidant tests to maximize the use of phytonutrients in food quality control and pharmaceutical research. Prospects: Future directions seek to address the challenges discovered through the development of multidisciplinary research and testing technologies. Novel approaches will advance our knowledge of phytonutrient potency and aid in developing medicines and nutraceuticals. This study highlights the significance of trustworthy assays for understanding and utilizing phytonutrients, providing academics and professionals in the business with vital insights.

PHYTONutrients

The effect of crocin on the proliferation, inflammation, drug synergism, and angiogenesis in breast cancer

Antioxidant Assays in Phytonutrient Research: Translating Laboratory Innovations into Practical Applications